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Bleeding problems or stomach ulcers. Liver and kidney problems, including being on dialysis. How to Use Sildenafil Safely. When you’re dealing with ED, it can understandably trigger a range of ...
Sildenafil’s ability to increase blood flow makes the medication useful for managing other conditions. Some sources suggest Viagra might make you last longer in bed, and others say it’s good ...
These medications increase blood flow to the tissue inside your member, which makes it easier to get hard from intimate stimulation. ... Viagra doses range from 25 to 100 milligrams (mg). A ...
Chemical structure of sildenafil (Viagra), the prototypical PDE5 inhibitor. A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues.
It requires sexual arousal to work, and does not by itself cause or increase sexual arousal. [8] It also results in dilation of the blood vessels in the lungs. [8] Pfizer originally discovered the medication in 1989 while looking for a treatment for angina. [11] It was approved for medical use in the United States and in the European Union in 1998.
Sildenafil (marketed as Viagra) was the first PDE5 inhibitor on the market. Originally created as a treatment for high blood pressure in 1989, it was found to have a secondary use as an effective PDE5 inhibitor, enabling men who use it to gain stronger erections after arousal. The FDA approved Viagra on March 27, 1998. [20]
Many of these pills work fairly quickly. Sildenafil (Viagra), tadalafil (Cialis) and vardenafil (Levitra) typically start working within 30 to 60 minutes, while avanafil (Stendra) works within 15 ...
Research has found that taking Viagra does not increase high blood pressure. Sildenafil, the active ingredient in Viagra, is actually used to treat a certain kind of high blood pressure in the lungs.