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As per Falkow's original descriptions, the three postulates are: [1] "The phenotype or property under investigation should be associated with pathogenic members of a genus or pathogenic strains of a species. Specific inactivation of the gene(s) associated with the suspected virulence trait should lead to a measurable loss in pathogenicity or ...
Falkow is known as the father of the field of molecular microbial pathogenesis. [1] He formulated molecular Koch's postulates, which have guided the study of the microbial determinants of infectious diseases since the late 1980s. [2] Falkow spent over 50 years uncovering molecular mechanisms of how bacteria cause disease and how to disarm them. [1]
Microbial pathogenesis is a field of microbiology that started at least as early as 1988, with the identification of the triune Falkow's criteria, aka molecular Koch's postulates.
In 1988, microbiologist Stanley Falkow developed a set of three Molecular Koch's postulates for identifying the microbial genes encoding virulence factors. First, the phenotype of a disease symptom must be associated with a specific genotype only found in pathogenic strains. Second, that symptom should not be present when the associated gene is ...
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To the right is a molecular dynamics (MD) simulation in which 900 hard sphere particles are constrained to move in a rectangle. They interact via perfectly elastic collisions . The system is initialized out of equilibrium, but the velocity distribution (in blue) quickly converges to the 2D Maxwell–Boltzmann distribution (in orange).
Much like you can't make a boy and a girl fall in love with each other simply by pushing them together, you cannot make precise chemistry occur as desired between two molecular objects with simple mechanical motion along a few degrees of freedom in the assembler-fixed frame of reference. Chemistry, like love, is more subtle than that.
Association theory (also aggregate theory) is a theory first advanced by chemist Thomas Graham in 1861 to describe the molecular structure of colloidal substances such as cellulose and starch, now understood to be polymers. Association theory postulates that such materials are solely composed of a collection of smaller molecules bound together ...