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Tubular carcinoma is a subtype of invasive ductal carcinoma of the breast. [ 2 ] [ 3 ] More rarely, tubular carcinomas may arise in the pancreas [ 4 ] or kidney. [ 5 ] Most tubular carcinomas begin in the milk duct of the breast and spread to healthy tissue around it.
Ductal carcinoma in situ is seen at left as lumina with micropapillary formations (under the larger bland cyst), and was presumably the precursor lesion for the ductal carcinoma. Reference for typical features: Pragya Virendrakumar Jain, M.D., Julie M. Jorns, M.D.. Breast - Other invasive carcinoma subtypes, WHO classified - Tubular.
Molecular classification of breast cancer from mRNA expression profiles. DNA microarrays have compared normal cells to breast cancer cells and found differences in the expression of hundreds of genes. Although the significance of many of those genetic differences is unknown, independent analyses by different research groups has found that ...
For breast pathology, also in distinguishing usual ductal hyperplasia (UDH) and papillary lesions (having a mosaic-like pattern) from ductal carcinoma in situ, which is usually negative. [1] Cyclin D1 and CK5/6 staining could be used in concert to distinguish between the diagnosis of papilloma (Cyclin D1 < 4.20%, CK 5/6 positive) or papillary ...
Tubular areas (see adjacent photomicrograph of a tubular carcinoma) consist of well-formed tubules lined with mostly normal appearing tubular cells. [ 17 ] [ 20 ] The other histopathological patterns that may occur in these tumor types include the pattern associated with invasive carcinoma of no special type [ 4 ] or in uncommon cases the ...
Medullary breast carcinoma is a rare type of breast cancer [1] that is characterized as a relatively circumscribed tumor [2] with pushing, rather than infiltrating, margins. It is histologically characterized as poorly differentiated cells with abundant cytoplasm and pleomorphic high grade vesicular nuclei. [ 3 ]
Infiltrating duct and tubular carcinoma; ... M8543/3 Paget disease and intraductal carcinoma of breast (C50._) 8550 Acinar cell neoplasms. M8550/0 Acinar cell adenoma
On mammography, ILC shows spiculated mass with ill-defined margins that has similar or lower density than surrounding breast tissues. This happens only at 44–65% of the time. Architectural distortion on surrounding breast tissues is only seen in 10–34% of the cases. It can be reported as benign in 8–16% of the mammography cases. [10]