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Like many other medical conditions, obesity is the result of an interplay between environmental and genetic factors. [2] [3] Studies have identified variants in several genes that may contribute to weight gain and body fat distribution, although only in a few cases are genes the primary cause of obesity.
Fat mass and obesity-associated protein, also known as alpha-ketoglutarate-dependent dioxygenase FTO, is an enzyme that in humans is encoded by the FTO gene located on chromosome 16. As one homolog in the AlkB family proteins, it is the first messenger RNA (mRNA) demethylase that has been identified. [ 5 ]
Chromosomes in humans can be divided into two types: autosomes (body chromosome(s)) and allosome (sex chromosome(s)). Certain genetic traits are linked to a person's sex and are passed on through the sex chromosomes. The autosomes contain the rest of the genetic hereditary information. All act in the same way during cell division.
Most chromosome abnormalities occur as an accident in the egg cell or sperm, and therefore the anomaly is present in every cell of the body. Some anomalies, however, can happen after conception, resulting in Mosaicism (where some cells have the anomaly and some do not). Chromosome anomalies can be inherited from a parent or be "de novo". This ...
Climbing obesity rates around the world aren't a concern; they've now become a full-fledged problem. Source: Centers for Disease Control & Prevention. In the "Global Burden of Disease" report from ...
In 2021, scientists reported sequencing a complete, female genome (i.e., without the Y chromosome). [4] [3] The human Y chromosome, consisting of 62,460,029 base pairs from a different cell line and found in all males, was sequenced completely in January 2022. [5] The current version of the standard reference genome is called GRCh38.p14 (July ...
Obesity BMI. The National Heart, Lung, and Blood Institute defines obesity as a body mass index (BMI) of 30 or more. BMI is a measurement of body fat based on a person’s height and weight. An ...
Perilipin 4, also known as S3-12, is a protein that in humans is encoded by the PLIN4 gene on chromosome 19. [5] [6] It is highly expressed in white adipose tissue, with lower expression in heart, skeletal muscle, and brown adipose tissue. [7] PLIN4 coats lipid droplets in adipocytes to protect them from lipases.