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Winters's formula, [1] named after R. W. Winters, [2] is a formula used to evaluate respiratory compensation when analyzing acid-base disorders in the presence of metabolic acidosis. [3][4] It can be given as: where HCO3− is given in units of mEq/L and P CO2 will be in units of mmHg.
Acid–base imbalance is an abnormality of the human body's normal balance of acids and bases that causes the plasma pH to deviate out of the normal range (7.35 to 7.45). In the fetus, the normal range differs based on which umbilical vessel is sampled (umbilical vein pH is normally 7.25 to 7.45; umbilical artery pH is normally 7.18 to 7.38). [1]
Generally, metabolic acidosis occurs when the body produces too much acid (e.g., lactic acidosis, see below section), there is a loss of bicarbonate from the blood, or when the kidneys are not removing enough acid from the body. Chronic metabolic acidosis is most often caused by a decreased capacity of the kidneys to excrete excess acids ...
Respiratory acidosis is a state in which decreased ventilation (hypoventilation) increases the concentration of carbon dioxide in the blood and decreases the blood's pH (a condition generally called acidosis). Carbon dioxide is produced continuously as the body's cells respire, and this CO2 will accumulate rapidly if the lungs do not adequately ...
Delta Ratio. In nephrology, the delta ratio, or " delta-delta " (denoted Δ/Δ), is a formula that can be used to evaluate whether a mixed acid–base disorder (metabolic acidosis) is present, and if so, assess its severity. The anion gap (AG) without potassium is calculated first and if a metabolic acidosis is present, results in either a high ...
the bicarbonate concentration in the blood at a CO 2 of 5.33 kPa, full oxygen saturation and 37 Celsius. [15] Base excess: −2 to +2 mmol/L The base excess is used for the assessment of the metabolic component of acid-base disorders, and indicates whether the person has metabolic acidosis or metabolic alkalosis. Contrasted with the bicarbonate ...
Davenport diagram. In acid base physiology, the Davenport diagram is a graphical tool, developed by Horace W. Davenport, that allows a clinician or investigator to describe blood bicarbonate concentrations and blood pH following a respiratory and/or metabolic acid-base disturbance. The diagram depicts a three-dimensional surface describing all ...
Metabolic alkalosis is an acid-base disorder in which the pH of tissue is elevated beyond the normal range (7.35–7.45). This is the result of decreased hydrogen ion concentration, leading to increased bicarbonate (HCO− 3), or alternatively a direct result of increased bicarbonate concentrations. The condition typically cannot last long if ...