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12 days ago my doctor doubled my dose of Glipizide XL (from 5mg once/day to 5mg twice/day). My weight has been stable for 9 or 10 months now, but in the 12 days since the Glipizide increase, I've gained 5 or 6 pounds. It may be water weight because it tends to come and go from day to day, but...
I lost weight due to diet changes and my doctor had me discontinue the glipizide when I reduced my AC1 from 11 to 5.9 in 3 months. From what I can figure out, the only reason why you would gain weight on glipizide is that you increase your food intake due to possible low blood sugar.
I was taking Glipizide XL (5mg 2x/day), another drug in the sulfonylurea class, and suddenly, with no change in diet or exercise, quickly gained 18 pounds. My weight had been stable for over a year. I never had lows, and eat 1200-1300 calories, 30-40 grams of carbs/day (how can I gain weight on THAT??).
I already take 2000mg of metformin extended release daily. When I saw my endocrinologist the end of December, she added 5mg of glipizide (also extended release), trying to counteract the highs I get after eating. I've read so much here and elsewhere about glipizide causing weight gain. I'm...
Glipizide is an older Sulfonylurea drug that stimulates the beta cells in the pancreas to produce more insulin. It iis controversial. It's opponents believe it may cause hypos, beta cell burnout, possible heart disease, and weight gain. Some believe it is better to go straight to insulin rather than risk sulfonylurea drugs.
Moment I stop my Glipizide my BG goes a little bit up (into the 150 to 175 mg/dL avg level) but start losing weight immediately. In fact before I started on Glipizide I lost 15 pounds in a span of 6 months. That’s when I got concerned and went to doc. My A1C at that time was 7.5. Not sure if it is typical to start losing weight at that level ...
I was overweight at that time, as the months went by on the two drugs I kept gaining weight and gaining weight, as my diabetes doctor noted every time I visited him for my check up. My appetite increased and I knew that I’d soon be 300 lbs if something weren’t done. Finally the doctor admitted that Actose does make you gain weight.
I've been of the opinion that Januvia does not cause weight gain and indeed I have lost about 20 pounds since the first week of January. That's with some effort of course. I didn't notice a huge difference in numbers though and now my doc has added Glipizide, still trying to get from A1C of 6.4 to in the 5's someplace.
It should be no surprise that weight gain, which is so highly related to the development and progression of type 2 diabetes, is associated with an increased risk of diabetic retinopathy. A 2021 study in Korea found that patients with recent diagnoses of type 2 diabetes that lost 10 percent of their body weight cut their risk of DR in half ...
The negative side effects of the sulfonylureas are listed as low BS and weight gain, I guess the weight gain caused byeating too much to compensate for the low BS. And that it can cause burn out of your beta cells so you lose your insulin producing capacities, that is a big one. But with such low doses as jwags is on, these side effects are ...