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  2. Metformin - Wikipedia

    en.wikipedia.org/wiki/Metformin

    Metformin inhibits cyclic AMP production, blocking the action of glucagon, and thereby reducing fasting glucose levels. [117] Metformin also induces a profound shift in the faecal microbial community profile in diabetic mice, and this may contribute to its mode of action possibly through an effect on glucagon-like peptide-1 secretion. [108]

  3. Peak-to-trough ratio - Wikipedia

    en.wikipedia.org/wiki/Peak-to-trough_ratio

    Peak-to-trough ratio in pharmacokinetics is the ratio of peak (C max) and trough (C min) levels of a drug over its dosing interval (τ) at steady state.. Peak-to-trough ratio (PTR), also known as peak-to-trough variation or peak-to-trough fluctuation, is a parameter in pharmacokinetics which is defined as the ratio of C max (peak) concentration and C min (trough) concentration over a dosing ...

  4. Pharmacokinetics - Wikipedia

    en.wikipedia.org/wiki/Pharmacokinetics

    Population pharmacokinetics seeks to identify the measurable pathophysiologic factors and explain sources of variability that cause changes in the dose-concentration relationship and the extent of these changes so that, if such changes are associated with clinically relevant and significant shifts in exposures that impact the therapeutic index ...

  5. Is There a "Best Time" to Take Metformin? - AOL

    www.aol.com/best-time-metformin-115700262.html

    Take liquid metformin at the same time each day and with food. Just like with the tablet version, make it a habit to take liquid metformin at the same time to avoid missing doses and with food ...

  6. 7 Benefits of Metformin (Including Weight Loss) - AOL

    www.aol.com/7-benefits-metformin-including...

    Here’s a sneak peak of what metformin can do: Aid in weight loss. Offer anti-tumor effects. ... The increased circulating levels of insulin have direct effects on the ovaries, including excess ...

  7. Metformin may be as safe as insulin to treat diabetes during ...

    www.aol.com/metformin-may-safe-insulin-treat...

    Experts say that metformin and insulin can also be used together to help women with type 2 diabetes and gestational diabetes manage blood glucose levels during pregnancy. Metformin is just as safe ...

  8. Biological half-life - Wikipedia

    en.wikipedia.org/wiki/Biological_half-life

    Caesium in the body has a biological half-life of about one to four months. Mercury (as methylmercury) in the body has a half-life of about 65 days. Lead in the blood has a half life of 28–36 days. [29] [30] Lead in bone has a biological half-life of about ten years. Cadmium in bone has a biological half-life of about 30 years.

  9. Trough level - Wikipedia

    en.wikipedia.org/wiki/Trough_level

    In a medicine that is administered periodically, the trough level should be measured just before the administration of the next dose in order to avoid overdosing. [3] A trough level is contrasted with a "peak level" (C max), which is the highest level of the medicine in the body, and the "average level", which is the mean level over time. It is ...

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