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The human stratum corneum comprises several levels of flattened corneocytes that are divided into two layers: the stratum disjunctum and stratum compactum. The skin's protective acid mantle and lipid barrier sit on top of the stratum disjunctum. [5] The stratum disjunctum is the uppermost and loosest layer of skin. The stratum compactum is the ...
The lipids ultimately form the lamellar lipid bilayer that surrounds corneocytes and also contributes to the permeability barrier homeostasis of the stratum corneum. [12] The homeostasis function is regulated by the calcium gradient in the epidermis. [17] Usually the calcium level is very low in stratum corneum, but high in stratum granulosum.
2D projection of a 3D OCT-tomogram of the skin at the fingertip, depicting the stratum corneum (≈500 μm thick) with the stratum disjunctum on top and the stratum lucidum in the middle. At the bottom are the superficial parts of the dermis. The sweat ducts are clearly visible. (See also: Rotating 3D Version)
It forms the outermost layer of the skin and the inner lining of the mouth, esophagus and vagina. [2] In the epidermis of skin in mammals, reptiles, and birds, the layer of keratin in the outer layer of the stratified squamous epithelial surface is named the stratum corneum. Stratum corneum is made up of squamous cells which are keratinized and ...
The ability of the skin to hold water is primarily due to the stratum corneum and is critical for maintaining healthy skin. [24] Skin hydration is quantified using corneometry. [25] Lipids arranged through a gradient and in an organized manner between the cells of the stratum corneum form a barrier to transepidermal water loss. [26] [27]
The human epidermis is composed of stratified squamous epithelial cells, which further break down into four to five layers: the stratum corneum, stratum granulosum, stratum spinosum and stratum basale. Where the skin is thicker, such as in the palms and soles, there is an extra layer of skin between the stratum corneum and the stratum ...
Sebaceous glands secrete the skin lubricant sebum. Sebum is secreted onto the hair shaft and it prevents the hair from splitting. It consists mostly of lipids. After the sebum spreads along and up the hair shaft, it is distributed over the skin surface where it lubricates and waterproofs the outer layer of the skin, the stratum corneum. [1] [2]
The skin is made up of three microscopic layers: epidermis, dermis, and hypodermis. The epidermis is composed of stratified squamous epithelium and is divided into the following five sublayers or strata, listed in order from outer to inner: Stratum corneum, Stratum lucidum, Stratum granulosum, Stratum spinosum,