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The β-galactosidase-catalyzed reaction that activates the contrast agent. In a tissue where active β-galactosidase is present, the sugar will be cleaved from the rest of the compound. This permits water to access the paramagnetic center, and causes the magnetic relaxation properties of the surrounding water molecules to change.
A contrast agent (or contrast medium) is a substance used to increase the contrast of structures or fluids within the body in medical imaging. [1] Contrast agents absorb or alter external electromagnetism or ultrasound , which is different from radiopharmaceuticals , which emit radiation themselves.
Iodinated contrast contains iodine.It is the main type of radiocontrast used for intravenous administration.Iodine has a particular advantage as a contrast agent for radiography because its innermost electron ("k-shell") binding energy is 33.2 keV, similar to the average energy of x-rays used in diagnostic radiography.
Allergic reactions are rare. [1] The use of barium during pregnancy is safe for the baby; however, X-rays may result in harm. [4] Barium sulfate suspension is typically made by mixing barium sulfate powder with water. [1] It is a non-iodinated contrast media. [5] Barium sulfate has been known since the Middle Ages. [6]
Contrast-induced nephropathy (CIN) is a purported form of kidney damage in which there has been recent exposure to medical imaging contrast material without another clear cause for the acute kidney injury. Despite extensive speculation, the actual occurrence of contrast-induced nephropathy has not been demonstrated in the literature. [1]
Contrast CT, or contrast-enhanced computed tomography (CECT), is X-ray computed tomography (CT) using radiocontrast. Radiocontrasts for X-ray CT are generally iodine-based types . [ 1 ] This is useful to highlight structures such as blood vessels that otherwise would be difficult to delineate from their surroundings.
Contrast CT of a patient with brain metastases from breast cancer, before (left) and after (right) injection of iodinated contrast.. Iodinated contrast is a form of water-soluble, intravenous radiocontrast agent containing iodine, which enhances the visibility of vascular structures and organs during radiographic procedures.
Diatrizoate, also known as amidotrizoate, Gastrografin, is a contrast agent used during X-ray imaging. [1] This includes visualizing veins, the urinary system, spleen, and joints, as well as computer tomography (CT scan). [1] It is given by mouth, injection into a vein, injection into the bladder, through a nasogastric tube, or rectally. [2] [3]