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Pancreatic serous cystadenoma is a benign tumour of the pancreas. [2] It is usually solitary and found in the body or tail of the pancreas, and may be associated with von Hippel–Lindau syndrome . [ 2 ]
Most pancreatic cysts are benign and the risk of malignancy (pancreatic cancer) is 0.5-1.5%. Pancreatic pseudocysts and serous cystadenomas (which collectively account for 15-25% of all pancreatic cysts) are considered benign pancreatic cysts with a risk of malignancy of 0%. [1] Causes range from benign to malignant.
Mean age of presentation is at 45 years old. About 30% of biliary cystadenoma can progressively become malignant over time. [1] Endometrioid cystadenoma (8380) Appendix: The term mucinous cystadenoma is an obsolete term for appendiceal mucinous neoplasm [2] The term "cystadenoma" may also refer to a hidrocystoma. [3]
Pancreatic intraductal papillary mucinous tumors (most common diagnosis - 52.6%) Pancreatic serous cystic tumors (20.6%) Pancreatic serous cystadenoma; Pancreatic serous cystadenocarcinoma; Pancreatic mucinous cystic tumors (13.4%) Pancreatic mucinous cystadenoma; Pancreatic mucinous cystadenocarcinoma
Cystadenocarcinoma is a malignant form of a cystadenoma and is a cancer derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur.
Serous cystadenocarcinoma is a serous tumor in the cystadenocarcinoma grouping.. Most commonly, the primary site of serous cystadenocarcinoma is the ovary.Rare occurrence in the pancreas has been reported, although this is not typical, with the majority of microcystic pancreatic masses representing alternate disease processes such as the more benign serous cystadenoma.
Benign cystadenomas are the most common cystic tumors of the pancreas accounting for 75% of the cases. On average, mucinous accounts for 40–50% of cystic tumors, and serous cytadenoma accounts for 30% of it. Mucinous cystadenomas are in the distal pancreas in about 80% of the cases and distal pancreatectomy is needed for resection. [4]
Apart from pancreatic serous cystadenomas, which are almost always benign, four types of precancerous lesion are recognized. The first is pancreatic intraepithelial neoplasia (PanIN). These lesions are microscopic abnormalities in the pancreas and are often found in autopsies of people with no diagnosed cancer.