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Low dose aspirin is recommended to prevent pre-eclampsia and eclampsia in those at high risk. [12] Other preventative recommendations include calcium supplementation in areas with low calcium intake and treatment of prior hypertension with anti-hypertensive medications. [2] [3] Exercise during pregnancy may also be useful. [1]
Recommendations for prevention include: aspirin in those at high risk, calcium supplementation in areas with low intake, and treatment of prior hypertension with medications. [ 4 ] [ 5 ] In those with pre-eclampsia, delivery of the baby and placenta is an effective treatment [ 4 ] but full recovery can take days or weeks. [ 13 ]
Preeclampsia, the most severe type of HDP, has been a major subject of research for scientists. Preeclampsia is usually characterized by elevated blood pressure and frequently protein in the urine after the 20th week of pregnancy, believed to be caused by abnormal placental growth leading to endothelial dysfunction and inflammation.
In addition, aspirin induces the formation of NO-radicals in the body, which have been shown in mice to have an independent mechanism of reducing inflammation. This reduced leukocyte adhesion is an important step in the immune response to infection; however, evidence is insufficient to show aspirin helps to fight infection. [52]
For many infections, the baby is more at risk at particular stages of pregnancy. Problems related to perinatal infection are not always directly noticeable. [citation needed] The term TORCH complex refers to a set of several different infections that may be caused by transplacental infection: T - Toxoplasmosis
Preterm birth is a significant cost factor in healthcare, not even considering the expenses of long-term care for individuals with disabilities due to preterm birth. A 2003 study in the U.S. determined neonatal costs to be $224,400 for a newborn at 500–700 g versus $1,000 at over 3,000 g.
Additionally, aspirin induces the formation of NO-radicals in the body, which have been shown in mice to have an independent mechanism of reducing inflammation. This reduces leukocyte adhesion, which is an important step in immune response to infection. There is currently insufficient evidence to show that aspirin helps to fight infection. [18]
Tocolytics are used in preterm labor, which refers to when a baby is born too early before 37 weeks of pregnancy. As preterm birth represents one of the leading causes of neonatal morbidity and mortality, the goal is to prevent neonatal morbidity and mortality through delaying delivery and increasing gestational age by gaining more time for other management strategies like corticosteroids ...
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