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However, when combined with other medications or pathologies it can further elevate serum triglyceride levels to pathologic levels. [1] Substantial increases in serum triglyceride levels can lead to certain clinical signs and the development of acute pancreatitis. Familial hypertriglyceridemia falls in the Fredrickson-Levy and Lee's (FLL ...
Hypertriglyceridemia is the presence of high amounts of triglycerides in the blood.Triglycerides are the most abundant fatty molecule in most organisms. Hypertriglyceridemia occurs in various physiologic conditions and in various diseases, and high triglyceride levels are associated with atherosclerosis, even in the absence of hypercholesterolemia (high cholesterol levels) and predispose to ...
Familial hypertriglyceridemia is an autosomal dominant condition occurring in approximately 1% of the population. [27] This form is due to high triglyceride level. Other lipoprotein levels are typically within the normal reference range or slightly increased. [28] Treatment include diet control, fibrates and niacins. Although statins are ...
Olezarsen, sold under the brand name Tryngolza, is a medication used in the treatment of familial chylomicronemia syndrome. [1] [2] Olezarsen is an apolipoprotein C-III-directed antisense oligonucleotide. [1] It is given by injection under the skin. [1] Olezarsen was approved for medical use in the United States in December 2024.
Lomitapide, sold under the brand name Juxtapid in the US and Lojuxta in the EU, is a medication used as a lipid-lowering agent for the treatment of familial hypercholesterolemia, developed by Aegerion Pharmaceuticals. [3] It has been tested in clinical trials as single treatment and in combinations with atorvastatin, ezetimibe and fenofibrate ...
Certain drugs, such as estrogen, corticosteroids, retinoids, protease inhibitors, thiazide diuretics, and beta-blockers, may cause hypertriglyceridemia. Obesity increases the risk of hyperlipidemia. Chronic, excessive alcohol use increases the risk of hypertriglyceridemia. Smoking and not exercising may lead to hyperlipidemia.
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