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Somatostatin is secreted by delta cells at several locations in the digestive system, namely the pyloric antrum, the duodenum and the pancreatic islets. [14]Somatostatin released in the pyloric antrum travels via the portal venous system to the heart, then enters the systemic circulation to reach the locations where it will exert its inhibitory effects.
In both species, the peptide hormone Urocortin III (Ucn3) is a major local signal that is released from beta cells (and alpha cells in primates) to induce the local secretion of somatostatin. [3] It has also been suggested that somatostatin may be implicated in insulin-induced hypoglycaemia through a mechanism involving SGLT-2 receptors.
Somatostatin is encoded by a CRE and is very susceptible to gene promoter region activation by transcription factor CREB. [1] There are five known somatostatin receptors: [2] SST 1 ; SST 2 ; SST 3 ; SST 4 ; SST 5 ; All are G protein-coupled seven transmembrane receptors.
20607 Ensembl ENSG00000278195 ENSMUSG00000044933 UniProt P32745 P30935 RefSeq (mRNA) NM_001051 NM_001278687 NM_009218 NM_001356961 RefSeq (protein) NP_001042 NP_001265616 NP_033244 NP_001343890 Location (UCSC) Chr 22: 37.2 – 37.21 Mb Chr 15: 78.42 – 78.43 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Shekel Somatostatin receptor type 3 is a protein that in humans is encoded by ...
The somatostatin hormone itself can negatively affect the uptake of hormones in the body and may play a role in some hormonal conditions. Somatostatin 2 receptors have been found in concentration on the surface of tumor cells, particularly those associated with the neuroendocrine system where the overexpression of somatostatin can lead to many complications [22] [23] Due to this, these ...
Somatostatin receptor type 5 is a protein that in humans is encoded by the SSTR5 gene. [5] Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biological effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner.
Enteroendocrine cells are specialized cells of the gastrointestinal tract and pancreas with endocrine function. They produce gastrointestinal hormones or peptides in response to various stimuli and release them into the bloodstream for systemic effect, diffuse them as local messengers, or transmit them to the enteric nervous system to activate nervous responses.
20605 Ensembl ENSG00000139874 ENSMUSG00000035431 UniProt P30872 P30873 RefSeq (mRNA) NM_001049 NM_009216 RefSeq (protein) NP_001040 NP_033242 Location (UCSC) Chr 14: 38.21 – 38.21 Mb Chr 12: 58.26 – 58.26 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Somatostatin receptor type 1 is a protein that in humans is encoded by the SSTR1 gene. Function Somatostatin acts at many sites ...