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Mucuna pruriens is a tropical legume native to Africa and tropical Asia and widely naturalized and cultivated. [2] Its English common names include monkey tamarind , velvet bean , Bengal velvet bean , Florida velvet bean , Mauritius velvet bean , Yokohama velvet bean , cowage , cowitch , lacuna bean , and Lyon bean . [ 2 ]
l-DOPA, also known as l-3,4-dihydroxyphenylalanine and used medically as levodopa, is made and used as part of the normal biology of some plants [2] and animals, including humans. Humans, as well as a portion of the other animals that utilize l -DOPA, make it via biosynthesis from the amino acid l -tyrosine .
Mucuna is a genus of around 114 accepted species of climbing lianas (vines) and shrubs of the family Fabaceae: tribe Phaseoleae, typically found in tropical and subtropical forests in the Americas, sub-Saharan Africa, southern, southeastern, and eastern Asia, New Guinea, Australia, and the Pacific Islands.
However, when consumed as a botanical extract, for example from M pruriens supplements, a peripheral DOPA decarboxylase inhibitor is not present. [ 8 ] Inbrija (previously known as CVT-301) is an inhaled powder formulation of levodopa indicated for the intermittent treatment of "off episodes" in patients with Parkinson's disease currently ...
L-DOPA is transformed into dopamine in the dopaminergic neurons by dopa-decarboxylase. [3] Since motor symptoms are produced by a lack of dopamine in the substantia nigra, the administration of L-DOPA temporarily diminishes the motor symptoms. [3] Only 5–10% of L-DOPA crosses the blood–brain barrier.
However, there are also a variety of plants that contain L-DOPA, the metabolic precursor of dopamine. [146] The highest concentrations are found in the leaves and bean pods of plants of the genus Mucuna, especially in Mucuna pruriens (velvet beans), which have been used as a source for L-DOPA as a drug. [147]
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When in fact l-Dopa IS the main drug for Parkinson’s treatment, and has been for years. The whole mucuna pruriens as herbal medicine aspect needs to be dropped. I feel the article as now written is about as accurate as saying that arsenic is a traditional medication, and then listing out all of the potential “benefits” of arsenic.
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