Search results
Results from the WOW.Com Content Network
When he added nasal mucus, he found that the mucus inhibited the bacterial growth. [15] Surrounding the mucus area was a clear transparent circle (1 cm from the mucus), indicating the killing zone of bacteria, followed by a glassy and translucent ring beyond which was an opaque area indicating normal bacterial growth. In the next test, he used ...
In the contaminated plate the bacteria around the mould did not grow, while those farther away grew normally, meaning that the mould killed the bacteria. [6] Fleming commented as he watched the plate: "That's funny". [5] [6] Pryce remarked to Fleming: "That's how you discovered lysozyme."
Lysozyme's active site binds the peptidoglycan molecule in the prominent cleft between its two domains. It attacks peptidoglycans (found in the cell walls of bacteria, especially Gram-positive bacteria), its natural substrate, between N-acetylmuramic acid (NAM) and the fourth carbon atom of N-acetylglucosamine (NAG). [citation needed]
Abraham completed his DPhil at the University of Oxford under the supervision of Sir Robert Robinson, during which he was the first to crystallise lysozyme, [1] [7] an enzyme discovered by Sir Alexander Fleming and shown to have antibacterial properties, and was later the first enzyme to have its structure solved using X-ray crystallography, by ...
Howard Walter Florey was born in Malvern, a southern suburb of Adelaide, South Australia, on 24 September 1898. [2] His surname rhymes with "sorry". [3] He was the only son of Joseph Florey, a bootmaker from Oxfordshire in England, who as a boy moved to London where Florey's grandfather established a bootmaking business.
This was first done for lysozyme, an enzyme found in tears, saliva, and egg whites that digests the coating of some bacteria; the structure was solved by a group led by David Chilton Phillips and published in 1965. [23]
Many species of bacteria are subject to lysis by the enzyme lysozyme, found in animal saliva, egg white, and other secretions. [1] Phage lytic enzymes produced during bacteriophage infection are responsible for the ability of these viruses to lyse bacterial cells. [2]
On testing against different bacteria, he found that the mould could kill only certain Gram-positive bacteria. [27] Staphylococcus , Streptococcus , and diphtheria bacillus ( Corynebacterium diphtheriae ) were easily killed, but there was no effect on typhoid bacterium ( Salmonella typhimurium ) and a bacterium once thought to cause influenza ...