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The causes of schizophrenia that underlie the development of schizophrenia, a psychiatric disorder, are complex and not clearly understood.A number of hypotheses including the dopamine hypothesis, and the glutamate hypothesis have been put forward in an attempt to explain the link between altered brain function and the symptoms and development of schizophrenia.
Whereas most studies find only a modest effect of hypoxia in schizophrenia, a longitudinal study using a combination of indicators to detect possible fetal hypoxia, such as early equivalents of neurologic soft signs or obstetric complications, reported that the risk of schizophrenia and other nonaffective psychoses was "strikingly elevated" (5. ...
Onset typically occurs between the late teens and early 30s, with the peak incidence occurring in males in the early to mid-twenties, and in females in the late twenties. [3] [10] [18] Onset before the age of 17 is known as early-onset, [73] and before the age of 13, as can sometimes occur, is known as childhood schizophrenia or very early-onset.
'This will turn out to be the most important break in the disease,' the Broad Institute's director Eric Lander said.
Schizophrenia affects around 0.3–0.7% of the general population at some point in life (i.e. lifetime prevalence), [1] or 21 million people worldwide as of 2020 (about one of every 285). [2] By using precise methods in its diagnosis and a large, representative population, schizophrenia seems to occur with relative consistency over time during ...
It is possible that hazardous alcohol use via a kindling mechanism can cause the development of a chronic substance-induced psychotic disorder, i.e. schizophrenia. The effects of an alcohol-related psychosis include an increased risk of depression and suicide as well as causing psychosocial impairments. [66]
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