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RNFL asymmetry has been proposed as a strong indicator of optic neuritis, [7] [8] with one small study proposing that asymmetry of 5–6μm was "a robust structural threshold for identifying the presence of a unilateral optic nerve lesion in MS." [9] Optic neuritis is often associated with multiple sclerosis, and RNFL data may indicate the pace ...
Retinal ganglion cells make up the optic nerve and have a long unmyelinated portion, hence the high energy demand and sensitivity to mitochondrial dysfunction. This is especially the case for smaller axons such as those found in the papillomacular bundle of the retina , which transmit information corresponding to the central visual field .
The optic nerve contains axons of nerve cells that emerge from the retina, leave the eye at the optic disc, and go to the visual cortex where input from the eye is processed into vision. There are 1.2 million optic nerve fibers that derive from the retinal ganglion cells of the inner retina. [2] Damage to the optic nerve can have different causes:
Lesions involving the whole optic nerve cause complete blindness on the affected side, that means damage at the right optic nerve causes complete loss of vision in the right eye. [3] Optic neuritis involving external fibers of the optic nerve causes tunnel vision. [4] Optic neuritis involving internal fibers of the optic nerve causes central ...
However, action potentials in this system are not being received by the second or third thoracic vertebrae which innervates the face, neck, and upper chest. [3] Harlequin syndrome,caused by a defect in sympathetic innervation. Damage or lesions near T2 or T3 could be between the stellate ganglion and superior cervical ganglion. This is where we ...
Major symptoms are sudden loss of vision (partial or complete), sudden blurred or "foggy" vision, and; pain on movement of the affected eye. [4] [5] [2]Many patients with optic neuritis may lose some of their color vision in the affected eye (especially red), with colors appearing subtly washed out compared to the other eye.
It is composed of two individual tracts, the left optic tract and the right optic tract, each of which conveys visual information exclusive to its respective contralateral half of the visual field. Each of these tracts is derived from a combination of temporal and nasal retinal fibers from each eye that corresponds to one half of the visual field.
Leber's hereditary optic neuropathy (LHON) is a mitochondrially inherited (transmitted from mother to offspring) degeneration of retinal ganglion cells (RGCs) and their axons that leads to an acute or subacute loss of central vision; it predominantly affects adult males, and onset is more likely in younger adults.