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In genetics, chromosome translocation is a phenomenon that results in unusual rearrangement of chromosomes. This includes balanced and unbalanced translocation, with two main types: reciprocal, and Robertsonian translocation. Reciprocal translocation is a chromosome abnormality caused by exchange of parts between non-homologous chromosomes. Two ...
Translocation may refer to: Chromosomal translocation, a chromosome abnormality caused by rearrangement of parts Robertsonian translocation, a chromosomal rearrangement in pairs 13, 14, 15, 21, and 22; Nonreciprocal translocation, transfer of genes from one chromosome to another; PEP group translocation, a method used by bacteria for sugar uptake
For example, 46,XY,der(4)t(4;8)(p16;q22)t(4;9)(q31;q31) would refer to a derivative chromosome 4 which is the result of a translocation between the short arm of chromosome 4 at region 1, band 6 and the long arm of chromosome 8 at region 2, band 2, and a translocation between the long arm of chromosome 4 at region 3, band 1 and the long arm of ...
Paternally-derived chromosome rearrangement psu dic: pseudo dicentric – only one centromere in a dicentric chromosome is active q: Long arm of a chromosome r: Ring chromosome t: Translocation: ter: Terminal end of arm (e.g. 2qter refers to the end of the long arm of chromosome 2) tri: Trisomy: trp: Triplication of a portion of a chromosome
In genetics, a chromosomal rearrangement is a mutation that is a type of chromosome abnormality involving a change in the structure of the native chromosome. [1] Such changes may involve several different classes of events, like deletions, duplications, inversions, and translocations.
In genetics, a fusion gene is a hybrid gene formed from two previously independent genes. It can occur as a result of translocation , interstitial deletion , or chromosomal inversion . Fusion genes have been found to be prevalent in all main types of human neoplasia . [ 1 ]
The result is a single, large chromosome with a metacentric centromere. This form of rearrangement is a Robertsonian translocation. [citation needed] This type of translocation may involve homologous (paired) or non-homologous chromosomes. Owing to the acrocentric nature of the chromosomes involved, the long arms of these chromosomes contain ...
This figure depicts how Floxing is used in scientific research for spatial and temporal control of gene expression. In genetic engineering, floxing refers to the insertion of a DNA sequence (which is then said to be floxed) between two LoxP sequences, creating an artificial gene cassette which can then be conditionally deleted (knocked out), translocated, or inverted in a process called Cre ...