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Tolvaptan, sold under the brand name Samsca among others, is an aquaretic drug that functions as a selective, competitive vasopressin receptor 2 (V 2) antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).
It is a prodrug of tolvaptan, [1] [2] formulated as the salt tolvaptan sodium phosphate, for intravenous administration. Tolvaptan phosphate is converted into the active drug tolvaptan in the human body following administration. It was developed by Otsuka Pharmaceutical Co. and was approved for use in Japan in 2022. [3]
24 News (Twenty Four News) is a free-to-air Indian Malayalam language news channel owned by Insight Media City. It was initially launched as a pilot in 2016 and officially began operations on December 8, 2018. The channel is headquartered in Kochi and has studios in Thiruvananthapuram and Kochi.
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India Today was established in 1975 [7] by Vidya Vilas Purie (owner of Thompson Press), with his daughter Madhu Trehan as its editor and his son Aroon Purie as its publisher. [8] [9] At present, India Today is also published in Hindi, Tamil, Malayalam and Telugu. The India Today news channel was launched on 22 May 2015.
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