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Side-effects of amikacin are similar to those of other aminoglycosides. Kidney damage and ototoxicity (which can lead to hearing loss) are the most important effects, occurring in 1–10% of users. [17] The nephro- and ototoxicity are thought to be due to aminoglycosides' tendency to accumulate in the kidneys and inner ear. [8] Diagram of the ...
While antibiotics are safe and effective for treating uncomplicated appendicitis, [16] [7] [82] 31% of people had a recurrence within a year and required an eventual appendectomy. [83] Antibiotics are less effective if an appendicolith is present. [84]
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Antibiotics by class Generic name Brand names Common uses [4] Possible side effects [4] Mechanism of action Aminoglycosides; Amikacin: Amikin: Infections caused by Gram-negative bacteria, such as Escherichia coli and Klebsiella particularly Pseudomonas aeruginosa. Effective against aerobic bacteria (not obligate/facultative anaerobes) and ...
There has been significant recent trial evidence that uncomplicated appendicitis can be treated with either antibiotics or appendicectomy, [4] [5] with 51% of those treated with antibiotics avoiding an appendectomy after 3 years. [6] After appendicectomy the main difference in treatment is the length of time the antibiotics are administered.
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The incidence of inner ear toxicity varies from 7 to 90%, depending on the types of antibiotics used, susceptibility of the patient to such antibiotics, and the duration of antibiotic administration. [20] Another serious and disabling side effect of aminoglycoside use is vestibular ototoxicity. [19]
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