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The WHO Model List of Essential Medicines for Children (aka Essential Medicines List for Children [1] or EMLc [1]), published by the World Health Organization (WHO), contains the medications considered to be most effective and safe in children up to twelve years of age to meet the most important needs in a health system.
Prednisolone has a relatively short half-life, ranging 2–4 hours. It also has a large therapeutic window, considering the dosage required to produce a therapeutic effect is a few times higher than what the body naturally produces. [14] Prednisolone is 70–90% plasma protein bound, it binds to proteins such as albumin. [14]
A separate list for children up to 12 years of age, known as the WHO Model List of Essential Medicines for Children (EMLc), was created in 2007 and is in its 9th edition. [ 10 ] [ 21 ] [ 22 ] [ 23 ] It was created to make sure that the needs of children were systematically considered such as availability of proper formulations .
Methylprednisolone dosage and administration for these diseases is highly variable due to varied pathophysiology between the diseases and within patients diagnosed with a given disease. [ 17 ] [ 18 ] In Lupus Nephritis, a common manifestation of SLE, patients are often prescribed methylprednisolone concomitantly with immunosuppressants.
The neuropsychiatric effects are partly mediated by sensitization of the body to the actions of adrenaline. Therapeutically, the bulk of corticosteroid dose is given in the morning to mimic the body's diurnal rhythm; if given at night, the feeling of being energized will interfere with sleep. An extensive review is provided by Flores and Gumina ...
Characteristics of Synthetic Glucocorticoids Synthetic Glucocorticoid Equivalent Dose (mg) Anti-inflammatory Activity 1 Mineralocorticoid Activity 1 Biological Half Life (hrs) References Short-to medium-acting glucocorticoids: Hydrocortisone 20 1 1 8–12 [25] [26] Cortisone 25 0.8 0.8 8–12 [25] [26] Prednisone 5 4 0.3 12–36 [25] [26 ...
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Prednisolone tebutate is a synthetic glucocorticoid corticosteroid and a corticosteroid ester. [1] References This page was last edited on 26 August 2023, at 13: ...