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The endogenous ligand of these receptors is anandamide, the effects of which THC emulates. This agonism of the cannabinoid receptors results in changes in the levels of various neurotransmitters, especially dopamine and norepinephrine, which are closely associated with the acute effects of cannabis ingestion, such as euphoria and anxiety.
A participant in a study on the effects of cannabis, shows the marijuana flowers he has grown in his backyard, in Longmont, Colorado, U.S., December 19, 2019.
Over time, the marijuana gateway hypothesis has been studied more and more. In one published study, the use of marijuana was shown not a reliable gateway cause of illicit drug use. [67] However, social factors and environment influence drug use and abuse, making the gateway effects of cannabis different for those in differing social circumstances.
The long-term and short-term effects of cannabis use are associated with behavioral effects leading to a wide variety of effects on the body systems and physiological states. [14] CHS is a paradoxical syndrome characterized by hyperemesis (persistent vomiting), as opposed to the better known antiemetic properties of cannabinoids . [ 15 ]
Cannabis use disorder is diagnosed when a person has two or more of such symptoms as craving weed, becoming tolerant to its effects, using more than intended, using marijuana even though it causes ...
On the positive side, a 2020 research article published in BMC Psychiatry concluded that there is "encouraging, albeit embryonic" (meaning, early stage) evidence for using medicinal cannabis to ...
The time to onset of effects depends strongly on stomach content, but is usually 1 to 2 hours, and may continue for a considerable length of time, whereas the effects of smoking or vaporizing cannabis are almost immediate, lasting a shorter length of time. [10] All of the active constituents enter the body when cannabis is consumed orally.
More young children are getting sick from inadvertently eating marijuana edibles, according to a study published Tuesday in the journal Pediatrics.. Calls to poison control centers about kids 5 ...