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Magic bullet (medicine) The magic bullet is a scientific concept developed by the German Nobel laureate Paul Ehrlich in 1907. [ 1 ] While working at the Institute of Experimental Therapy (Institut für experimentelle Therapie), Ehrlich formed an idea that it could be possible to kill specific microbes (such as bacteria), which cause diseases in ...
Paul Ehrlich. Paul Ehrlich (German: [ˈpaʊl ˈʔeːɐ̯lɪç] ⓘ; 14 March 1854 – 20 August 1915) was a Nobel Prize -winning German physician and scientist who worked in the fields of hematology, immunology and antimicrobial chemotherapy. Among his foremost achievements were finding a cure for syphilis in 1909 and inventing the precursor ...
Dr. Ehrlich's Magic Bullet. Dr. Ehrlich's Magic Bullet is a 1940 American biographical film starring Edward G. Robinson and directed by William Dieterle, based on the true story of the German doctor and scientist Dr. Paul Ehrlich. The film was released by Warner Bros., with some controversy over raising the subject of syphilis in a major studio ...
Arsphenamine. The structure of arsphenamine has been proposed to be akin to azobenzene (A), but chemical studies published in 2005 suggest [1] that salvarsan is actually a mixture of the trimer (B) and the pentamer (C). Arsphenamine, also known as Salvarsan or compound 606, is an antibiotic drug that was introduced at the beginning of the 1910s ...
Schematic structure of an antibody–drug conjugate (ADC) Antibody–drug conjugates or ADCs are a class of biopharmaceutical drugs designed as a targeted therapy for treating cancer. [1] Unlike chemotherapy, ADCs are intended to target and kill tumor cells while sparing healthy cells. As of 2019, some 56 pharmaceutical companies were ...
Sahachiro Hata. Sahachirō Hata (秦 佐八郎, Hata Sahachirō, March 23, 1873 – November 22, 1938) was a prominent Japanese bacteriologist who researched the bubonic plague under Kitasato Shibasaburō and assisted in developing the antisyphilitic drug arsphenamine in 1909 in the laboratory of Paul Ehrlich. Hata received three unsuccessful ...
As a graduate student working with Nobelist Dr. David Baltimore, Dr. Daley demonstrated that the BCR/ABL oncogene induces chronic myeloid leukemia (CML) in a mouse model, [6] which validated BCR/ABL as a target for drug blockade and encouraged the development of imatinib (Gleevec; Novartis), a magic-bullet chemotherapy that induces remissions ...
Monoclonal antibody. A general representation of the method used to produce monoclonal antibodies [1] [2] A monoclonal antibody (mAb, more rarely called moAb) is an antibody produced from a cell lineage made by cloning a unique white blood cell. All subsequent antibodies derived this way trace back to a unique parent cell.