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In TLS, the breakdown occurs after cytotoxic therapy or from cancers with high cell turnover and tumor proliferation rates. [4] The metabolic abnormalities seen in tumor lysis syndrome can ultimately result in serious complications such as acute uric acid nephropathy , acute kidney failure , seizures , cardiac arrhythmias , and death.
Transport Layer Security (TLS) is a cryptographic protocol designed to provide communications security over a computer network, such as the Internet.The protocol is widely used in applications such as email, instant messaging, and voice over IP, but its use in securing HTTPS remains the most publicly visible.
In computer programming, thread-local storage (TLS) is a memory management method that uses static or global memory local to a thread. The concept allows storage of data that appears to be global in a system with separate threads. Many systems impose restrictions on the size of the thread-local memory block, in fact often rather tight limits.
The ability of the immune system to recognize molecules that are broadly shared by pathogens is, in part, due to the presence of immune receptors called toll-like receptors (TLRs) that are expressed on the membranes of leukocytes including dendritic cells, macrophages, natural killer cells, cells of the adaptive immunity T cells, and B cells, and non-immune cells (epithelial and endothelial ...
The publishing of TLS 1.3 and DTLS 1.3 obsoleted TLS 1.2 and DTLS 1.2. Note that there are known vulnerabilities in SSL 2.0 and SSL 3.0. In 2021, IETF published RFC 8996 also forbidding negotiation of TLS 1.0, TLS 1.1, and DTLS 1.0 due to known vulnerabilities. NIST SP 800-52 requires support of TLS 1.3 by January 2024.
In order to decide what protection is to be provided for an outgoing packet, IPsec uses the Security Parameter Index (SPI), an index to the security association database (SADB), along with the destination address in a packet header, which together uniquely identifies a security association for that packet. A similar procedure is performed for ...
The activity of tyrosine kinases is typically regulated in an auto-inhibitory fashion, but the BCR-ABL1 fusion gene codes for a protein that is "always on" or constitutively activated, leading to impaired DNA binding and unregulated cell division (i.e. cancer).
Cellular immunity, also known as cell-mediated immunity, is an immune response that does not rely on the production of antibodies. Rather, cell-mediated immunity is the activation of phagocytes , antigen-specific cytotoxic T-lymphocytes , and the release of various cytokines in response to an antigen .