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A more focused functional genomics approach might test the function of all variants of one gene and quantify the effects of mutants by using sequencing as a readout of activity. Together these measurement modalities endeavor to quantitate the various biological processes and improve our understanding of gene and protein functions and interactions.
Sequence analysis tasks are often non-trivial to resolve and require the use of relatively complex approaches, many of which are the backbone behind many existing sequence analysis tools. Of the many methods used in practice, the most popular include the following: Dynamic programming; Artificial neural network; Hidden Markov model; Support ...
For enzymes, predictions of specific functions are especially difficult, as they only need a few key residues in their active site, hence very different sequences can have very similar activities. By contrast, even with sequence identity of 70% or greater, 10% of any pair of enzymes have different substrates; and differences in the actual ...
Activity exercise-whether one is able to do daily activities normally without any problem, self care activities Sleep rest-do they have hypersomnia, insomnia, do they have normal sleeping patterns Cognitive-perceptual-assessment of neurological function is done to assess, check the person's ability to comprehend information
The Corsi block tapping task originated in the early 1970s [2] as a set of 9 identical wooden blocks positioned on a board. The subject was required to point at the blocks in the order they were presented, or "tapped". It was based on the digit span task, but instead of the verbal form of the Digit Span, it required the use of visuo-spatial ...
While MNase-seq is primarily used to sequence regions of DNA bound by histones or other chromatin-bound proteins, [2] the other three are commonly used for: mapping Deoxyribonuclease I hypersensitive sites (DHSs), [6] sequencing the DNA unbound by chromatin proteins, [7] or sequencing regions of loosely packaged chromatin through transposition ...
The ORF Finder (Open Reading Frame Finder) [16] is a graphical analysis tool which finds all open reading frames of a selectable minimum size in a user's sequence or in a sequence already in the database. This tool identifies all open reading frames using the standard or alternative genetic codes.
In 2010, for the first time, the genes responsible for the unique adaptive traits were identified following genome sequencing of 50 Tibetans and 40 Han Chinese from Beijing. Initially, the strongest signal of natural selection was a transcription factor involved in response to hypoxia, called endothelial Per-Arnt-Sim (PAS) domain protein 1 ...