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The hypothalamic–pituitary–somatotropic axis (HPS axis), or hypothalamic–pituitary–somatic axis, also known as the hypothalamic–pituitary–growth axis, is a hypothalamic–pituitary axis which includes the secretion of growth hormone (GH; somatotropin) from the somatotropes of the pituitary gland into the circulation and the subsequent stimulation of insulin-like growth factor 1 ...
If there is an excess of growth hormone, it is usually because of over-secretion of somatotrope cells in the anterior pituitary gland. A significant amount of excess somatotrope secretion before puberty or before the end of new bone tissue growth can lead to gigantism, a disease that causes excess growth of body (e.g. being over 7 ft. tall) and unusually long limbs.
Growth hormone (GH) or somatotropin, also known as human growth hormone (hGH or HGH) in its human form, is a peptide hormone that stimulates growth, cell reproduction, and cell regeneration in humans and other animals. It is thus important in human development.
The intermediate lobe is present in many animal species, particularly in rodents, mice, and rats, which have been used extensively to study pituitary development and function. [6] In all animals, the fleshy, glandular anterior pituitary is distinct from the neural composition of the posterior pituitary, which is an extension of the hypothalamus .
Growth hormone–releasing hormone (GHRH), also known as somatocrinin among other names in its endogenous form and as somatorelin in its pharmaceutical form, is a releasing hormone of growth hormone (GH). It is a 44 [1]-amino acid peptide hormone produced in the arcuate nucleus of the hypothalamus.
growth hormone release–inhibiting hormone or somatotropin release–inhibiting factor or somatotropin release–inhibiting hormone) GHIH or GHRIH or SRIF or SRIH Peptide: hypothalamus, islets of Langerhans, gastrointestinal system: delta cells in islets Neuroendocrince cells of the Periventricular nucleus in hypothalamus: Somatostatin receptor
For more information, patients treated with cadaver-derived human growth hormone in the U.S. can call the National Institute of Diabetes and Digestive and Kidney Diseases at 1-800-860-8747 or ...
Anterior hypophysis, neurosecretory cells which release hormones. There is a pituitary portal system, with which the hormones are transported. These hormones are prolactin, growth hormone, TSH, adrenocorticotropic hormone, FSH and LH. They are all released by anterior pituitary. Some have targets in glands and some with direct function.