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Smallpox was an infectious disease caused by variola virus (often called smallpox virus), which belongs to the genus Orthopoxvirus. [7] [11] The last naturally occurring case was diagnosed in October 1977, and the World Health Organization (WHO) certified the global eradication of the disease in 1980, [10] making smallpox the only human disease to have been eradicated to date.
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Diseases associated with this genus include smallpox, cowpox, horsepox, camelpox, and mpox. [ 1 ] [ 2 ] The most widely known member of the genus is Variola virus , which causes smallpox. It was eradicated globally by 1977, through the use of Vaccinia virus as a vaccine .
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The name of the family, Poxviridae, is a legacy of the original grouping of viruses associated with diseases that produced poxes on the skin.Modern viral classification is based on phenotypic characteristics; morphology, nucleic acid type, mode of replication, host organisms, and the type of disease they cause.
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The Massachusetts smallpox epidemic or colonial epidemic was a smallpox outbreak that hit Massachusetts in 1633. [1] Smallpox outbreaks were not confined to 1633 however, and occurred nearly every ten years. [2] Smallpox was caused by two different types of variola viruses: variola major and variola minor. [3]