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Metamizole or dipyrone is a painkiller, spasm reliever, and fever reliever drug. It is most commonly given by mouth or by intravenous infusion. [13] [11] [14] It belongs to the ampyrone sulfonate family of medicines and was patented in 1922. Metamizole is marketed under various trade names.
[3] [4] The compounds generally act as analgesics and include dipyrone (Metamizole), aminophenazone, ampyrone, famprofazone, morazone, nifenazone, piperylon and propyphenazone. Of these dipyrone is perhaps the most widely used. [3] [5] The basic structure has been also used in a number of newer drugs of other effects. [5]
Aminophenazone (or aminopyrine, amidopyrine, Pyramidon) is a non-narcotic analgesic substance. It is a pyrazolone and a derivative of phenazone, which also has anti-inflammatory and antipyretic properties.
Ampyrone is a metabolite of aminopyrine with analgesic, anti-inflammatory, and antipyretic properties. [2] While the parent drug, aminopyrine, has been discouraged due to the risk of agranulocytosis, [3] [4] ampyrone itself has significantly lower toxicity. [5]
Dipyrone 1975 UK, US, Others Agranulocytosis, anaphylactic reactions. [3] Dithiazanine iodide: 1964 France, US Cardiovascular and metabolic reaction. [3] Dofetilide: 2004 Germany Drug interactions, prolonged QT. [14] Drotrecogin alfa (Xigris) 2011 Worldwide Lack of efficacy as shown by PROWESS-SHOCK study [19] [20] [21] Ebrotidine: 1998 Spain
Difenamizole (INN; brand name Pasalin; former developmental code name AP-14) is a nonsteroidal anti-inflammatory drug (NSAID) and analgesic of the pyrazolone group related to metamizole. [1]
An equianalgesic chart is a conversion chart that lists equivalent doses of analgesics (drugs used to relieve pain). Equianalgesic charts are used for calculation of an equivalent dose (a dose which would offer an equal amount of analgesia) between different analgesics. [1]
Phenazone (INN and BAN; also known as phenazon, antipyrine (), antipyrin, [1] or analgesine) is an analgesic (pain reducing), antipyretic (fever reducing) and anti-inflammatory drug.