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Metamizole or dipyrone is a painkiller, spasm reliever, and fever reliever drug. It is most commonly given by mouth or by intravenous infusion. [13] [11] [14] It belongs to the ampyrone sulfonate family of medicines and was patented in 1922. Metamizole is marketed under various trade names.
Aminophenazone (or aminopyrine, amidopyrine, Pyramidon) is a non-narcotic analgesic substance. It is a pyrazolone and a derivative of phenazone, which also has anti-inflammatory and antipyretic properties.
[3] [4] The compounds generally act as analgesics and include dipyrone (Metamizole), aminophenazone, ampyrone, famprofazone, morazone, nifenazone, piperylon and propyphenazone. Of these dipyrone is perhaps the most widely used. [3] [5] The basic structure has been also used in a number of newer drugs of other effects. [5]
Dipyrone 1975 UK, US, Others Agranulocytosis, anaphylactic reactions. [3] Dithiazanine iodide: 1964 France, US Cardiovascular and metabolic reaction. [3] Dofetilide: 2004 Germany Drug interactions, prolonged QT. [14] Drotrecogin alfa (Xigris) 2011 Worldwide Lack of efficacy as shown by PROWESS-SHOCK study [19] [20] [21] Ebrotidine: 1998 Spain
Ampyrone is a metabolite of aminopyrine with analgesic, anti-inflammatory, and antipyretic properties. [2] While the parent drug, aminopyrine, has been discouraged due to the risk of agranulocytosis, [3] [4] ampyrone itself has significantly lower toxicity. [5]
Date: 16 February 2022: Source: Own work, blank map from File:BlankMap-World.svg, converted from File:Metamizole legal status by country2.png. To edit the map, open the SVG file in a text editor, all the instructions are there, its easier than it seems.
Difenamizole (INN; brand name Pasalin; former developmental code name AP-14) is a nonsteroidal anti-inflammatory drug (NSAID) and analgesic of the pyrazolone group related to metamizole. [1]
Phenazone (INN and BAN; also known as phenazon, antipyrine (), antipyrin, [1] or analgesine) is an analgesic (pain reducing), antipyretic (fever reducing) and anti-inflammatory drug.