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In biochemistry and medicinal chemistry, phosphonate groups are used as stable bioisosteres for phosphate, such as in the antiviral nucleotide analog, Tenofovir, one of the cornerstones of anti-HIV therapy. And there is an indication that phosphonate derivatives are "promising ligands for nuclear medicine." [2]
Phosphonates are esters of phosphonic acid and have the general formula RP(=O)(OR') 2. Phosphonates have many technical applications, a well-known member being glyphosate, better known as Roundup. With the formula (HO) 2 P(O)CH 2 NHCH 2 CO 2 H, this derivative of glycine is one of the most widely used herbicides.
Although they are derivatives of phosphonous acid (RP(OH) 2), [2] they are not prepared from such precursors. Phosphonites are prepared by alcoholysis of organophosphinous chlorides. For example, treatment of dichlorophenylphosphine with methanol and base gives dimethyl phenylphosphonite: Cl 2 PPh + 2 CH 3 OH → (CH 3 O) 2 PPh + 2 HCl
Phosphonates are salts (M 2 HPO 3) or esters (OP(OR) 2 R) of phosphonic acid Subcategories. This category has the following 2 subcategories, out of 2 total. P ...
Phosphonates are more difficult to hydrolyse than phosphates. [3] ... Examples. Aminomethylphosphonic acid (AMPA), the simplest possible aminophosphonate.
This nomenclature is commonly reserved for substituted derivatives, that is, organic group bonded to phosphorus, not simply an ester. For example, (CH 3 )PO(OH) 2 is " methylphosphonic acid ", which may of course form "methyl phosphonate " esters .
The Duthane cocktail, for example, blends raki, mastic, and white mulberry. Foxy Local wine expert Levon Bağış and celebrity chef Maksut Aşkar are behind Foxy , an always-packed wine bar in ...
The insecticide fosthietan is a phosphoramidate. In organophosphorus chemistry, phosphoramidates (sometimes also called amidophosphates) are a class of phosphorus compounds structurally related to phosphates (or organophosphates) via the substitution of an −O − group for an amine group (−N−).