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Biological responses to ligand concentrations typically follow a sigmoidal function. The inflection point at which the increase in response with increasing ligand concentration begins to slow is the EC 50, which can be mathematically determined by derivation of the best-fit line.
Example of concentration-response model used to calculate EC50. Toxciant concentration is on the X-axis and biological response is on the Y-axis. Point estimation is a technique to predict population parameters based on available sample data and can be used to relate the mass based concentration to a toxicity based metric.
AAT Bioquest Online IC50 Calculator; Online IC50 calculator (www.ic50.tk) based on the C programming language and gnuplot; Alternative online IC50 calculator (www.ic50.org) based on Python, NumPy, SciPy and Matplotlib; ELISA IC50/EC50 Online Tool (link seems broken) IC50 to pIC50 calculator; Online tool for analysis of in vitro resistance to ...
The parameters of the dose response curve reflect measures of potency (such as EC50, IC50, ED50, etc.) and measures of efficacy (such as tissue, cell or population response). A commonly used dose–response curve is the EC 50 curve, the half maximal effective concentration, where the EC 50 point is defined as the inflection point of the curve.
The relationship between and EC50 may be quite complex as a biological response will be the sum of myriad factors; a drug will have a different biological effect if more receptors are present, regardless of its affinity.
In pharmacology, an effective dose (ED) or effective concentration (EC) is the dose or concentration of a drug that produces a biological response. [1] [2] The term "effective dose" is used when measurements are taken in vivo, while "effective concentration" is used when the measurements are taken in vitro.
The light measured directly correlates to the toxicity of the sample, producing data that allows for the calculation of EC50 or IC50s, or other ECxx and ICxx values. [14] Acute Toxicity Basic Test is a procedure that measures the relative acute toxicity of a sample. This test is the best protocol for testing samples of unknown toxicity, a high ...
Acute toxicity data includes LC50 and EC50 data. This data is frequently screened for quality, relevancy and ideally contains data for species in multiple trophic levels and/or taxonomic groups. [1] [6] The lowest LC50 in the compiled database is then divided by the assessment factor to calculate the PNEC for that data. The assessment factor ...