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CBD has recently become the talk of the town for its potential role in pain relief. Once a niche, it now dominates the wellness sphere, attracting a diverse audience seeking relief for various pains.
Cannabidiol (CBD) is a phytocannabinoid, one of 113 identified cannabinoids in cannabis plants, along with tetrahydrocannabinol (THC), and accounts for up to 40% of the plant's extract. [18] Medically, it is an anticonvulsant used to treat multiple forms of epilepsy. [4]
CBD is hydroxylated by P450 liver enzymes into 7-OH-CBD. Its metabolites are products of primarily CYP2C19 and CYP3A4 activity, with potential activity of CYP1A1, CYP1A2, CYP2C9, and CYP2D6. [69] Similar to delta-9-THC, a majority of CBD is excreted in feces and some in the urine. [57] The terminal half-life is approximately 18–32 hours. [70]
CBD shares a precursor with THC and is the main cannabinoid in CBD-dominant Cannabis strains. CBD has been shown to play a role in preventing the short-term memory loss associated with THC. [29] There is tentative evidence that CBD has an anti-psychotic effect, but research in this area is limited. [30] [24]
This is sponsored content. Us Weekly is not endorsing the websites or products set forth below. The use of THC in any capacity may lead to health concerns and users should consult medical ...
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