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Hypercoagulability in pregnancy is the propensity of pregnant women to develop thrombosis (blood clots). Pregnancy itself is a factor of hypercoagulability (pregnancy-induced hypercoagulability), as a physiologically adaptive mechanism to prevent post partum bleeding. [1] However, when combined with an additional underlying hypercoagulable ...
Blood coagulation pathways in vivo showing the central role played by thrombin. Health. Beneficial. Coagulation, also known as clotting, is the process by which blood changes from a liquid to a gel, forming a blood clot. It results in hemostasis, the cessation of blood loss from a damaged vessel, followed by repair.
An amniotic fluid embolism (AFE) is a life-threatening childbirth (obstetric) emergency in which amniotic fluid enters the blood stream of the mother, triggering a serious reaction which results in cardiorespiratory (heart and lung) collapse and massive bleeding (coagulopathy). [1][2][3] The rate at which it occurs is 1 instance per 20,000 ...
The last category, alterations in the constitution of blood, [6] has numerous possible risk factors such as hyperviscosity, coagulation factor V Leiden mutation, coagulation factor II G2021A mutation, deficiency of antithrombin III, protein C or S deficiency, nephrotic syndrome, changes after severe trauma or burn, cancer, late pregnancy and ...
The third and last step is called coagulation or blood clotting. Coagulation reinforces the platelet plug with fibrin threads that act as a "molecular glue". [3] Platelets are a large factor in the hemostatic process. They allow for the creation of the "platelet plug" that forms almost directly after a blood vessel has been ruptured.
There is also increased blood stasis due to the compression of the vena cava by the enlargening uterus. [26] Many factors have been shown to increase the risk of clots in pregnancy, including baseline thrombophilia, cesarean section, preeclampsia, etc. [23] Clots usually develop in the left leg or the left iliac/ femoral venous system. [27]
The risk of blood clotting is further increased by generalized hypercoagulability as concentrations of clotting factors rise during pregnancy. [8] This increased chance of blood clots leads to an increased risk of potentially fatal pulmonary or systemic emboli cutting off blood flow and oxygen to critical organs.
Prothrombin time. Blood plasma after the addition of tissue factor. The gel-like structure is strong enough to hold a steel ball. The prothrombin time (PT) – along with its derived measures of prothrombin ratio (PR) and international normalized ratio (INR) – is an assay for evaluating the extrinsic pathway and common pathway of coagulation.