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The mechanism for base-catalyzed aldol condensation can be seen in the image below. A mechanism for aldol condensation in basic conditions, which occurs via enolate intermediates and E1CB elimination. The process begins when a free hydroxide (strong base) strips the highly acidic proton at the alpha carbon of the aldehyde.
The aldol reaction (aldol addition) is a reaction in organic chemistry that combines two carbonyl compounds (e.g. aldehydes or ketones) to form a new β-hydroxy carbonyl compound. Its simplest form might involve the nucleophilic addition of an enolized ketone to another: These products are known as aldols, from the ald ehyde + alcoh ol, a ...
Claisen–Schmidt condensation. In organic chemistry, the Claisen–Schmidt condensation is the reaction between an aldehyde or ketone having an α-hydrogen with an aromatic carbonyl compound lacking an α-hydrogen. It can be considered as a specific variation of the aldol condensation. This reaction is named after two of its pioneering ...
Henry reaction. The Henry reaction is a classic carbon–carbon bond formation reaction in organic chemistry. Discovered in 1895 by the Belgian chemist Louis Henry (1834–1913), it is the combination of a nitroalkane and an aldehyde or ketone in the presence of a base to form β-nitro alcohols. [1][2][3] This type of reaction is also referred ...
Condensation reaction. In organic chemistry, a condensation reaction is a type of chemical reaction in which two molecules are combined to form a single molecule, usually with the loss of a small molecule such as water. [1] If water is lost, the reaction is also known as a dehydration synthesis. However other molecules can also be lost, such as ...
Proline-catalyzed aldol reactions. The Hajos–Parrish–Eder–Sauer–Wiechert and Barbas-List[1] reactions in organic chemistry are a family of proline -catalysed asymmetric aldol reactions. In the 1970s, two research groups discovered (and published) almost simultaneously their discoveries of two related intramolecular reactions: Zoltan ...
α,β-Unsaturated acids, esters, and amides. An α,β-unsaturated acid is a type of α,β-unsaturated carbonyl compound that consists of an alkene conjugated to a carboxylic acid. [ 3 ] The simplest example is acrylic acid (CH 2 =CHCO 2 H). These compounds are prone to polymerization, giving rise to the large area of polyacrylate plastics.
Generalised Tandem Michael-aldol reaction. Robinson annulation is one notable example of a wider class of chemical transformations termed Tandem Michael-aldol reactions, that sequentially combine Michael addition and aldol reaction into a single reaction. As is the case with Robinson annulation, Michael addition usually happens first to tether ...