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The Sonogashira reaction is a cross-coupling reaction used in organic synthesis to form carbon–carbon bonds. It employs a palladium catalyst as well as copper co-catalyst to form a carbon–carbon bond between a terminal alkyne and an aryl or vinyl halide. [1] The Sonogashira Reaction. The Sonogashira reaction.
A 3D model of ethyne (acetylene), the simplest alkyne. In organic chemistry, an alkyne is an unsaturated hydrocarbon containing at least one carbon —carbon triple bond. [1] The simplest acyclic alkynes with only one triple bond and no other functional groups form a homologous series with the general chemical formula CnH2n−2.
corey-fuchs-reaction. RSC ontology ID. RXNO:0000146. The Corey–Fuchs reaction, also known as the Ramirez–Corey–Fuchs reaction, is a series of chemical reactions designed to transform an aldehyde into an alkyne. [1] [2] [3] The formation of the 1,1-dibromoolefins via phosphine-dibromomethylenes was originally discovered by Desai, McKelvie ...
Carbonyl groups, for example, can successfully react with dienes to yield dihydropyran rings, a reaction known as the oxo-Diels–Alder reaction, and imines can be used, either as the dienophile or at various sites in the diene, to form various N-heterocyclic compounds through the aza-Diels–Alder reaction.
An alkyne trimerisation is a [2+2+2] cycloaddition reaction in which three alkyne units (C≡C) react to form a benzene ring. The reaction requires a metal catalyst. The process is of historic interest as well as being applicable to organic synthesis. [1] Being a cycloaddition reaction, it has high atom economy.
Click chemistry is an approach to chemical synthesis that emphasizes efficiency, simplicity, selectivity, and modularity in chemical processes used to join molecular building blocks. It includes both the development and use of "click reactions", a set of simple, biocompatible chemical reactions that meet specific criteria like high yield, fast ...
The azide-alkyne Huisgen cycloaddition is a 1,3-dipolar cycloaddition between an azide and a terminal or internal alkyne to give a 1,2,3-triazole. Rolf Huisgen [1] was the first to understand the scope of this organic reaction. American chemist Karl Barry Sharpless has referred to copper-catalyzed version of this cycloaddition as "the cream of ...
The alkyne representation of benzyne is the most widely encountered. Arynes are usually described as having a strained triple bond. [6] Geometric constraints on the triple bond in benzyne result in diminished overlap of in-plane p-orbitals, and thus weaker triple bond. [7] The vibrational frequency of the triple bond in benzyne was assigned by ...