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Addison Rerecich (October 1, 1999 – December 30, 2019) [1] was an American double-lung transplant recipient who spent the longest documented duration of time using extracorporeal membrane oxygenation (ECMO) therapy at 93 days. [2] [3] She underwent the transplant at age 11 in 2011 and was the subject of a 2013 episode of Frontline on PBS.
A 2019 cohort study of nearly 10,000 lung transplant recipients in the US demonstrated significantly improved long-term survival using sirolimus + tacrolimus (median survival 8.9 years) instead of mycophenolate mofetil + tacrolimus (median survival 7.1 years) for immunosuppressive therapy starting at one year after transplant.
Date of transplant Survival Reference Sandro (1945–2010) Argentine singer and actor. He died after complications of a heart–lung transplant. November 20, 2009 45 days [31] Ann Harrison (1944–2001) Recipient and long term survivor of the world's first human double-lung transplant November 26, 1986 15 years [90] Charity Sunshine Tillemann-Dick
Photo by NYU Langone Health. Cheryl Mehrkar with Stephanie H. Chang, MD, who performed the world’s first fully robotic double lung transplant surgery on Oct. 22, 2024.
Ex vivo lung perfusion, EVLP, is a form of machine perfusion aimed at sustaining the active aerobic cellular metabolism of donor lungs outside the donor's body prior to lung transplantation. This medical preservation technique typically occurs within a specialised machine engineered to mimic the conditions of the natural circulatory system .
Although controversial, the most recent data suggest that bilateral lung transplantation is superior to single lung transplantation in patients with IPF. [57] Five-year survival rates after lung transplantation in IPF are estimated at between 50 and 56%. [3] [58] [59]
Higher lung allocation scores indicate the patient is more likely to benefit from a lung transplant. The post-transplant survival measure is one-year survival after transplantation of the lungs . Factors used to predict it include FVC , ventilator use, age, creatinine , NYHA class and diagnosis. [ 3 ]
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