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Diabetes is the leading known cause of neuropathy in developed countries, and neuropathy is the most common complication and greatest source of morbidity and mortality in diabetes. A systematic review has found that diabetic peripheral neuropathy affects 30% of diabetes patients. [ 1 ]
Epalrestat is a carboxylic acid derivative [1] and a noncompetitive and reversible aldose reductase inhibitor used for the treatment of diabetic neuropathy, which is one of the most common long-term complications in patients with diabetes mellitus.
Proximal diabetic neuropathy, also known as diabetic amyotrophy, is a complication of diabetes mellitus that affects the nerves that supply the thighs, hips, buttocks and/or lower legs. Proximal diabetic neuropathy is a type of diabetic neuropathy characterized by muscle wasting, weakness, pain, or changes in sensation/numbness of the leg.
For example, insulin is used to treat type 1 diabetes. This helps make up for the insulin your body isn’t making. Besides insulin, other medications may be used to manage type 2 diabetes.
Another 2010 review of four trials, for the treatment of diabetic neuropathy, found significant improvement in pain and overall symptoms, with 38% of patients in one trial becoming asymptomatic. The treatment remains effective even after prolonged use, but symptoms return to baseline within a month of cessation of treatment. [104]
Although, Peripheral Mononeuropathy has no scientifically reached a point where the symptoms and effects can be reversed, patients can use medications, therapies, clinical trials, alternative medicines, lifestyle changes and home remedies in order to stop, slow and prevent the occurrence of peripheral mononeuropathy symptoms. [6]
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