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4-Fluoroaniline can be prepared by the hydrogenation of 4-nitrofluorobenzene. [2] It is a common building block in medicinal chemistry and related fields. [3] For example, it is a precursor to the fungicide fluoroimide or the fentanyl analogue parafluorofentanyl. It has also been evaluated for the production of ligands for homogeneous catalysis ...
Boiling point (°C) K b (°C⋅kg/mol) Freezing point (°C) K f (°C⋅kg/mol) Data source; Aniline: 184.3 3.69 –5.96 –5.87 K b & K f [1] Lauric acid: 298.9 44 –3.9 Acetic acid: 1.04 117.9 3.14 16.6 –3.90 K b [1] K f [2] Acetone: 0.78 56.2 1.67 –94.8 K b [3] Benzene: 0.87 80.1 2.65 5.5 –5.12 K b & K f [2] Bromobenzene: 1.49 156.0 6. ...
Section 3; Table 3.2 Physical Constants of Inorganic Compounds. ... "Estimation Chemical Form Boiling Point Elementary Astatine by Radio Gas Chromatography".
David R. Lide (ed), CRC Handbook of Chemistry and Physics, 85th Edition, online version. CRC Press. Boca Raton, Florida, 2003; Section 6, Fluid Properties; Critical Constants. Also agrees with Celsius values from Section 4: Properties of the Elements and Inorganic Compounds, Melting, Boiling, Triple, and Critical Point Temperatures of the Elements
Fluoroaniline may refer to three compounds with the formula FC 6 H 4 NH 2: 2-Fluoroaniline; 3-Fluoroaniline; 4-Fluoroaniline This page was last edited on 9 ...
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4-Fluoronitrobenzene can be hydrogenated to give 4-fluoroaniline, [3] which is a precursor to the fungicide fluoroimide and parafluorofentanyl. Owing to the presence of the electron withdrawing nitro group, the fluoride is a good leaving group in fluoronitrobenzenes. Thus reaction with phenoxide gives the mononitrodiphenylether. [4]
This is significantly stronger than the bonds of carbon with other halogens (an average bond energy of e.g. C-Cl bond is around 320 kJ/mol [1]) and is one of the reasons why fluoroorganic compounds have high thermal and chemical stability. The carbon–fluorine bond is relatively short (around 1.4 Å [1]).