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In trichophagia, people with trichotillomania also ingest the hair that they pull; in extreme (and rare) cases this can lead to a hair ball (trichobezoar). [10] Rapunzel syndrome is an extreme form of trichobezoar in which the "tail" of the hair ball extends into the intestines and can be fatal if misdiagnosed. [10] [18] [19] [20]
Rapunzel syndrome is an extremely rare intestinal condition in humans resulting from ingesting hair (trichophagia). [1] [2] The syndrome is named after the long-haired girl Rapunzel in the fairy tale by the Brothers Grimm. Trichophagia is sometimes associated with the hair-pulling disorder trichotillomania. [3]
Trichophagia is most closely associated with trichotillomania, the pulling out of one's own hair, and thus any symptoms of trichotillomania could be predictive of trichophagia and must be ruled out. Rarely, persons with trichophagia do not exclusively have trichotillomania and instead will eat the hair of others. [9] [5]
People with trichotillomania have a compulsion to pull out hair from their scalp, eyebrows or other areas of the body. ... there isn’t one single cause of trichotillomania. “Symptoms can start ...
'This will turn out to be the most important break in the disease,' the Broad Institute's director Eric Lander said.
The question of how schizophrenia could be primarily genetically influenced, given that people with schizophrenia have lower fertility rates, is a paradox. It is expected that genetic variants that increase the risk of schizophrenia would be selected against, due to their negative effects on reproductive fitness .
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