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When transferrin is high, HFE works to increase the intestinal release of iron into the blood. When HFE is mutated, the intestines perpetually interpret a strong transferrin signal as if the body were deficient in iron. This leads to maximal iron absorption from ingested foods and iron overload in the tissues.
Food products and household items commonly handled by humans can be toxic to dogs. The symptoms can range from simple irritation to digestion issues, behavioral changes, and even death. The categories of common items ingested by dogs include food products, human medication, household detergents, indoor and outdoor toxic plants, and rat poison. [1]
Iron overload (also known as haemochromatosis or hemochromatosis) is the abnormal and increased accumulation of total iron in the body, leading to organ damage. [1] The primary mechanism of organ damage is oxidative stress, as elevated intracellular iron levels increase free radical formation via the Fenton reaction.
While many dog owners know that giving Fido chocolate can causing poisoning, there other lesser known foods that need to be kept away from your dog. 9 types of food you should never feed your dog ...
Iron poisoning can occur when doses of 20 to 60 mg/kg or more of elemental iron is ingested with most cases reporting primarily gastrointestinal symptoms. [4] Systemic signs and symptoms shown in serious toxicity occur at higher doses exceeding 60 mg/kg. [5] Ingesting above 120 mg/kg may be fatal. [4]
Research has shown that dogs fed a meat-based whole-food diet have lower levels of compounds associated with increased inflammation and skin diseases in dogs (3).
The reason some dogs develop kidney failure following ingestion of grapes and raisins is not known. [3] Types of grapes involved include both seedless and seeded, store-bought and homegrown, and grape pressings from wineries. [4] A mycotoxin is suspected to be involved, but none has been found in grapes or raisins ingested by affected dogs. [5]
Skin conditions in dogs are very common, so it's important to recognize the symptoms and understand the factors that cause them. Dr. Rebecca MacMillan, a vet with over 15 years of experience, says ...
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