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Oncogenomics is a sub-field of genomics that characterizes cancer-associated genes.It focuses on genomic, epigenomic and transcript alterations in cancer. Cancer is a genetic disease caused by accumulation of DNA mutations and epigenetic alterations leading to unrestrained cell proliferation and neoplasm formation.
A proto-oncogene is a normal gene that could become an oncogene due to mutations or increased expression. Proto-oncogenes code for proteins that help to regulate the cell growth and differentiation. Proto-oncogenes are often involved in signal transduction and execution of mitogenic signals, usually through their protein products.
The chance of cancer cannot be reduced by removing proto-oncogenes from the genome, even if this were possible, as they are critical for the growth, repair, and homeostasis of the organism. It is only when they become mutated that the signals for growth become excessive. One of the first oncogenes to be defined in cancer research is the ras ...
On Dec. 7 at North Henderson High School, 11th grader Citlally Diaz, 17, was honored for winning one of just four $3,000 scholarship grand prize awards out of thousands of entries across the country.
A tumor suppressor gene (TSG), or anti-oncogene, is a gene that regulates a cell during cell division and replication. [1] If the cell grows uncontrollably, it will result in cancer . When a tumor suppressor gene is mutated, it results in a loss or reduction in its function.
These types of rearrangements are primarily associated with papillary thyroid carcinoma (PTC) where they represent 10-20% of cases, and non-small cell lung cancer (NSCLC) where they represent 2% of cases. Several fusion partners have been described in the literature, and the most common ones across both cancer types include KIF5B, CCDC6 and NCOA4.
Harold Eliot Varmus (born December 18, 1939) is an American Nobel Prize-winning scientist.He is currently the Lewis Thomas University Professor of Medicine at Weill Cornell Medicine and a senior associate at the New York Genome Center.
Oncogene received a 2023 impact factor of 6.9 and received Journal Citation Reports rankings of 18th out of 191 in the category Genetics & Heredity, 29th out of 205 in the category Cell Biology, 32nd out of 313 in the category Biochemistry & Molecular Biology, and 43rd out of 322 journals in the category Oncology. [3]