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John Truman Carter III, M.D. is a fictional character from the NBC television series ER. He was portrayed by Noah Wyle and appeared as one of the series' principal characters from the pilot episode until the eleventh-season finale .
For the first time John Carter becomes the central character and Noah Wyle receives star billing. The death of Mark Greene continues to affect his colleagues while a grieving Corday has left Chicago for England. She returns and a medical student raises eyebrows. The ER is still plagued by the smallpox disease at the beginning.
For the first time, John Carter is centered as the main character of the show at the end of the season. In this season, several staff members face personal and professional pressures, including Greene and Corday who face the most difficult issue of all when their baby overdoses on Ecstasy pills.
Carter treats a 16-year-old girl with kidney failure after taking a new drug to control her seizures. Carter's old medical student, George Henry, is the girl's doctor and is a paid consultant to the manufacturer. When things get worse, the father commits suicide so that he can give his daughter his remaining kidney.
Numerous college students come into the ER, victims of fraternity/sorority pledging pranks and hazing rituals. Carter and Abby take a road trip to Oklahoma to pick up Maggie, who has locked herself in a motel room; then she steals sleeping pills from a convenience store and attempts suicide. Rena dumps Carter over the phone.
Carter works in the Sudanese desert, helping treat hundreds of diseased people including a woman raped by a militant group. Back in the ER, the police accuse Clemente of shooting Jodie. Pratt and Neela work to save a 14-year-old involved in a hit-and-run accident, but Pratt is infuriated when he discovers who hit the young teen.
"The Show Must Go On" is the 22nd and final episode of the eleventh season, and the 245th episode overall, of the American television series ER. Written by David Zabel and directed by John Wells , the episode originally aired on NBC on May 19, 2005.
Rod Holcomb, the director of the 1994 pilot episode as well as several other early episodes, returned to direct two episodes in this season, among them the series finale; Paul McCrane, recurring cast member seasons 4 and 5, and series regular seasons 6–10, continues his affiliation with the show as director of two episodes this season