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4 Factors influencing bioavailability. 5 See ... this is known as absolute bioavailability ... Whether a drug is taken with or without food will also affect ...
The principal effect on BV in everyday life is the organism's current diet, although many other factors such as age, health, weight, sex, etc. all have an effect. In short any condition which can affect the organism's metabolism will vary the BV of a protein source.
Factors such as poor compound solubility, gastric emptying time, intestinal transit time, chemical instability in the stomach, and inability to permeate the intestinal wall can all reduce the extent to which a drug is absorbed after oral administration. Absorption critically determines the compound's bioavailability.
Factors that affect absorption include: The way a drug product is designed and manufactured; Its physical and chemical properties; Other ingredients it contains; The physiologic characteristics of the person taking the drug; How the drug is stored [11]
Temperature may affect metabolic transformation, and bioenergetics. An example of this is the movement of the organism may change as well as rates of excretion. [15] If a contaminant is ionic, the change in pH that is influenced by a change in temperature may also influence the bioavailability [1]
Grapefruit juice increases the bioavailability of sildenafil, the active ingredient in Viagra. It also delays your body’s processing of sildenafil. It also delays your body’s processing of ...
The relationship between the biological and plasma half-lives of a substance can be complex depending on the substance in question, due to factors including accumulation in tissues, protein binding, active metabolites, and receptor interactions. [7]
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