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A 2012 systematic review found that soluble urokinase-type plasminogen activator receptor (SuPAR) is a nonspecific marker of inflammation and does not accurately diagnose sepsis. [56] This same review concluded, however, that SuPAR has prognostic value, as higher SuPAR levels are associated with an increased rate of death in those with sepsis. [56]
Septic shock is a result of a systemic response to infection or multiple infectious causes. The precipitating infections that may lead to septic shock if severe enough include but are not limited to appendicitis, pneumonia, bacteremia, diverticulitis, pyelonephritis, meningitis, pancreatitis, necrotizing fasciitis, MRSA and mesenteric ischemia.
When sepsis occurs, it can cause inflammation and cause blood clotting around the body, if it does not get treated, it can result in death, organ failure and tissue damage, CDC says.
Sepsis can cause a drop in body temperature and severe shivering, which is one of a response to fighting infection, and is the body’s way of trying to increase its temperature. 3. Confusion
Neonatal sepsis of the newborn is an infection that has spread through the entire body. The inflammatory response to this systematic infection can be as serious as the infection itself. [26] In infants that weigh under 1500 g, sepsis is the most common cause of death. Three to four percent of infants per 1000 births contract sepsis.
Bacteremia can have several important health consequences. Immune responses to the bacteria can cause sepsis and septic shock, which, particularly if severe sepsis and then septic shock occurs, have high mortality rates, especially if not treated quickly (though, if treated early, currently mild sepsis can usually be dealt with successfully). [6]
Respiratory illnesses, allergies, and the early stages of sepsis may also cause chills, Cohan says. But there's always one more thing to consider with chills—a fever could still be on the horizon.
In septic patients, these clinical signs can also be seen in other proinflammatory conditions, such as trauma, burns, pancreatitis, etc. A follow-up conference, therefore, decided to define the patients with a documented or highly suspicious infection that results in a systemic inflammatory response as having sepsis. [18]