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Virus crystallisation is the re-arrangement of viral components into solid crystal particles. [1] The crystals are composed of thousands of inactive forms of a particular virus arranged in the shape of a prism. [2] The inactive nature of virus crystals provide advantages for immunologists to effectively analyze the structure and function behind ...
The importance of tobacco mosaic virus in the history of viruses cannot be overstated. It was the first virus to be discovered, and the first to be crystallised and its structure shown in detail. The first X-ray diffraction pictures of the crystallised virus were obtained by Bernal and Fankuchen in 1941.
Viruses may even have multiple origins and different types of viruses may have evolved independently over the history of life. [52] There are different hypotheses for the origins of viruses, for instance an early viral origin from the RNA world or a later viral origin from selfish DNA .
Gamma phage, an example of virus particles (visualised by electron microscopy) Virology is the scientific study of biological viruses.It is a subfield of microbiology that focuses on their detection, structure, classification and evolution, their methods of infection and exploitation of host cells for reproduction, their interaction with host organism physiology and immunity, the diseases they ...
1723 - Moritz Anton Cappeller introduced the term crystallography in his book Prodromus Crystallographiae De Crystallis Improprie Sic Dictis Commentarium. [3]1766 - Pierre-Joseph Macquer, in his Dictionnaire de Chymie, promoted mechanisms of crystallization based on the idea that crystals are composed of polyhedral molecules (primitive integrantes).
Tobacco mosaic virus was the first virus to be crystallized. It exhibit liquid crystal phases above a critical density [9]. It was achieved by Wendell Meredith Stanley in 1935 who also showed that TMV remains active even after crystallization. [5]
Crystals, though long admired for their regularity and symmetry, were not investigated scientifically until the 17th century. Johannes Kepler hypothesized in his work Strena seu de Nive Sexangula (A New Year's Gift of Hexagonal Snow) (1611) that the hexagonal symmetry of snowflake crystals was due to a regular packing of spherical water particles. [1]
Viral evolution is a subfield of evolutionary biology and virology that is specifically concerned with the evolution of viruses. [1] [2] Viruses have short generation times, and many—in particular RNA viruses—have relatively high mutation rates (on the order of one point mutation or more per genome per round of replication).