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Injuries to the ACL are common, 250,000 ACL injuries occur on an annual basis. This corresponds to a 1 in 3,000 chance of an individual sustaining an ACL injury. Ligaments in the ACL or meniscus are usually torn with an external force being applied to the knee joint. The ACL can be torn without an external force being applied [11]
The anterior cruciate ligament (ACL) of the knee is commonly injured. There is insufficient re-vascularization of the ligament after complete rupture, which limits its ability to heal and necessitates reconstruction surgery. Within the last 20 years, new types of synthetic ligaments have been developed.
ACL injuries in children are a challenge because children have open growth plates in the bottom of the femur or thigh bone and on the top of the tibia or shin. An ACL reconstruction typically crosses the growth plates, posing a theoretical risk of injury to the growth plate, stunting leg growth, or causing the leg to grow at an unusual angle. [18]
ACL reconstruction is a commonly practiced technique for ACL injury, conducted on 30% of patients, which manages to restore stability to the knee structure. [2] [14] Traditional ACL reconstructions uses autografts or allografts which demand a long rehabilitation time and in most cases, develop donor morbidity in the long term. [11]
Articular cartilage has a very limited capacity for self repair. Small damage does not repair itself and can often get worse over time. As cartilage is aneural and avascular (lack of nerve and blood supply, respectively), shallow damage often does not trigger pain. [citation needed]
Timing is important to wound healing. Critically, the timing of wound re-epithelialization can decide the outcome of the healing. [11] If the epithelization of tissue over a denuded area is slow, a scar will form over many weeks, or months; [12] [13] If the epithelization of a wounded area is fast, the healing will result in regeneration.
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