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Temsirolimus is a specific inhibitor of mTOR and interferes with the synthesis of proteins that regulate proliferation, growth, and survival of tumor cells. Though temsirolimus shows activity on its own, it is also known to be converted to sirolimus (rapamycin) in vivo; [4] therefore, its activity may be more attributed to its metabolite rather than the prodrug itself (despite claims to the ...
mTOR inhibitors are a class of drugs used to treat several human diseases, including cancer, autoimmune diseases, and neurodegeneration. They function by inhibiting the mammalian target of rapamycin (mTOR) (also known as the mechanistic target of rapamycin), which is a serine/threonine-specific protein kinase that belongs to the family of phosphatidylinositol-3 kinase (PI3K) related kinases ...
ATC code L04 Immunosuppressants is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products.
English: Skeletal formula of temsirolimus (brand name Torisel) — an mTOR inhibitor. Created with ChemDoodle and Adobe Illustrator CC 2017. Date: 19 February 2017:
2475 56717 Ensembl ENSG00000198793 ENSMUSG00000028991 UniProt P42345 Q9JLN9 RefSeq (mRNA) NM_004958 NM_001386500 NM_001386501 NM_020009 RefSeq (protein) NP_004949 NP_064393 Location (UCSC) Chr 1: 11.11 – 11.26 Mb Chr 4: 148.53 – 148.64 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The mammalian target of rapamycin (mTOR), also referred to as the mechanistic target of rapamycin ...
Sirolimus, also known as rapamycin and sold under the brand name Rapamune among others, is a macrolide compound that is used to coat coronary stents, prevent organ transplant rejection, treat a rare lung disease called lymphangioleiomyomatosis, and treat perivascular epithelioid cell tumour (PEComa).
7428 22346 Ensembl ENSG00000134086 ENSMUSG00000033933 UniProt P40337 P40338 RefSeq (mRNA) NM_000551 NM_198156 NM_001354723 NM_009507 RefSeq (protein) NP_000542 NP_937799 NP_001341652 NP_000542.1 NP_033533 Location (UCSC) Chr 3: 10.14 – 10.15 Mb Chr 6: 113.6 – 113.61 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The Von Hippel–Lindau tumor suppressor also known as pVHL is a ...
A protein kinase inhibitor (PKI) is a type of enzyme inhibitor that blocks the action of one or more protein kinases. [1] Protein kinases are enzymes that phosphorylate (add a phosphate, or PO 4, group) to a protein and can modulate its function.