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Secondary structure elements: α-helices (red), β-strands (blue arrows). [1] In molecular biology, an intrinsically disordered protein (IDP) is a protein that lacks a fixed or ordered three-dimensional structure, [2] [3] [4] typically in the absence of its macromolecular interaction partners, such as other proteins or RNA.
Discs large homolog 1 (DLG1), also known as synapse-associated protein 97 or SAP97, is a scaffold protein that in humans is encoded by the SAP97 gene. SAP97 is a mammalian MAGUK -family member protein that is similar to the Drosophila protein Dlg1 (the protein is alternatively referred to as hDlg1, and the human gene is DLG1).
The autoimmune regulator (AIRE) is a protein that in humans is encoded by the AIRE gene. [5] It is a 13kbp gene on chromosome 21q22.3 that encodes 545 amino acids. [6] AIRE is a transcription factor expressed in the medulla [broken anchor] (inner part) of the thymus.
2773 14679 Ensembl ENSG00000065135 ENSMUSG00000000001 UniProt P08754 Q9DC51 RefSeq (mRNA) NM_006496 NM_010306 RefSeq (protein) NP_006487 NP_034436 Location (UCSC) Chr 1: 109.55 – 109.6 Mb Chr 3: 108.01 – 108.05 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Guanine nucleotide-binding protein G(k) subunit alpha is a protein that in humans is encoded by the GNAI3 gene ...
The generation of a protein sequence is much easier than the determination of a protein structure. However, the structure of a protein gives much more insight in the function of the protein than its sequence. Therefore, a number of methods for the computational prediction of protein structure from its sequence have been developed. [39]
21954 Ensembl ENSG00000129991 ENSMUSG00000035458 UniProt P19429 Q6FGX2 P48787 RefSeq (mRNA) NM_000363 NM_009406 RefSeq (protein) NP_000354 NP_000354.4 NP_033432 Location (UCSC) Chr 19: 55.15 – 55.16 Mb Chr 7: 4.52 – 4.53 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Troponin I, cardiac muscle is a protein that in humans is encoded by the TNNI3 gene. It is a tissue-specific ...
Transcriptional repressor CTCF also known as 11-zinc finger protein or CCCTC-binding factor is a transcription factor that in humans is encoded by the CTCF gene. [ 5 ] [ 6 ] CTCF is involved in many cellular processes, including transcriptional regulation , insulator activity, V(D)J recombination [ 7 ] and regulation of chromatin architecture.
DNA damage-inducible transcript 3, also known as C/EBP homologous protein (CHOP), is a pro-apoptotic transcription factor that is encoded by the DDIT3 gene. [5] [6] It is a member of the CCAAT/enhancer-binding protein (C/EBP) family of DNA-binding transcription factors. [6]