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In rodents, the hippocampus is positioned so that, roughly, one end is near the top of the head (the dorsal or septal end) and one end near the bottom of the head (the ventral or temporal end). As shown in the figure, the structure itself is curved and subfields or regions are defined along the curve, from CA4 through CA1 (only CA3 and CA1 are ...
FVB mice, whose large litter sizes and large oocyte pronuclei expedite use in genetic research; Toxic milk mice, which fail to recruit nutrient copper into milk causing pup death. It is caused by an autosomal recessive mutation tx which arose in an inbred. Theophilos et al. 1996 found this to be genetic and localized to chromosome 8, near the ...
Rodents, mice and rats, have been the most prominent model organism since the discovery of modern neurons by Santiago Ramon y Cajal. Rodents have a very similar architecture and a complex nervous system with very little regenerative capacity similar to that found in humans. For that reason, rodents have been heavily used in pre-clinical testing.
The albino laboratory rat with its red eyes and white fur is an iconic model organism for scientific research in a variety of fields. Laboratory rats or lab rats are strains of the rat subspecies Rattus norvegicus domestica (Domestic Norwegian rat) which are bred and kept for scientific research.
In rodents as model organisms, the hippocampus has been studied extensively as part of a brain system responsible for spatial memory and navigation. [7] Many neurons in the rat and mouse hippocampi respond as place cells : that is, they fire bursts of action potentials when the animal passes through a specific part of its environment. [ 7 ]
Though rats and mice have similar place cells dynamics, mice have smaller place cells, and on the same size track have an increase in number of place fields per cell. Additionally, their replay is weaker compared to the replay in rats. [63] In addition to rats and mice, place cells have also been found in chinchillas. [60] [65]
The human brain is one of the most complex structures nature has ever devised, and that means there’s a lot we still don’t know about the three pounds of neurons and fat that rests between our ...
Since the brain regions are so specialized in their functioning, damages done to specific areas of the brain can cause specific type of damage. Damage to the left side of the brain can lead to language discrepancies, i.e. difficulty in properly identifying letters, numbers and words, inability to incorporate visual stimuli to comprehend ...