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The vomer (/ ˈ v oʊ m ər /; [1] [2] Latin: vomer, lit. 'ploughshare') is one of the unpaired facial bones of the skull . It is located in the midsagittal line, and articulates with the sphenoid , the ethmoid , the left and right palatine bones, and the left and right maxillary bones.
Iguratimod is an anti-inflammatory small molecule drug used for the treatment of rheumatoid arthritis, together with methotrexate in Japan and China. [1] As of 2015 the biological target was not known, but it prevents NF-κB activation and subsequently selectively inhibits COX-2 and several inflammatory cytokines.
Serious side effects may include kidney problems, low blood calcium, and osteonecrosis of the jaw. [3] Use during pregnancy may result in harm to the baby. [3] It is in the bisphosphonate family of medications. [3] It works by blocking the activity of osteoclast cells and thus decreases the breakdown of bone. [3]
The FDA approved only the five-mg, twice-daily dose on the grounds that a higher dose was not considered to have an adequate risk-to-benefit ratio. [32] In September 2020, the FDA approved tofacitinib for the treatment of children and adolescents two years of age and older with active polyarticular course juvenile idiopathic arthritis. [33]
Magnesium salicylate is a common analgesic [1] and nonsteroidal anti-inflammatory drug (NSAID) [2] used to treat mild to moderate musculoskeletal pain [3] such as in tendons and muscles. [ citation needed ] It is also used to treat joint pain like arthritis , [ 2 ] [ 3 ] general back pain , [ 4 ] and headaches .
Aceclofenac is a nonsteroidal anti-inflammatory drug (NSAID) analog of diclofenac. It is used for the relief of pain and inflammation in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. It was patented in 1983 and approved for medical use in 1992. [4]
A major disadvantage of the vomer flap surgery is the varying size and visibility of the vomer in different patients. If the vomer is not visible or too small to cover the cleft, the procedure cannot be done. Another disadvantage of the use of the vomer flap in the oral cavity is that the vomer tissue does not aesthetically match the oral mucosa.
Apremilast, sold under the brand name Otezla among others, is a medication for the treatment of certain types of psoriasis and psoriatic arthritis. [4] The drug acts as a selective inhibitor of the enzyme phosphodiesterase 4 (PDE4). [4] It is taken by mouth. [4]
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